Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction.
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Protein kinase C isozyme distribution and down-regulation in relation to insulin-stimulated c-fos induction.
Insulin can stimulate the expression of c-fos and other immediate early genes in many insulin-sensitive cell types. We found previously that this effect of insulin was essentially normal in cells in which protein kinase C (PKC) was down-regulated by 16 h of exposure to 16 microM phorbol 12-myristate 13-acetate (PMA). However, recent studies by other groups have suggested that much of the insuli...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)31946-4